ANTIBODY FOR SPECIFICALLY RECOGNIZING CLEAVAGE SURFACE OF C-TERMINAL FRAGMENT AFTER α-SECRETASE CLEAVAGE OF AMYLOID PRECURSOR PROTEIN AND USE THEREOF

摘要

The purpose of the present invention is to provide an antibody for specifically recognizing α-secretase cleavage products of APP. In particular, the present invention provides an antibody for recognizing αCTF and p3 peptide, particularly antibodies that do not recognize βCTF and Aβ. The present invention also provides antigen-binding fragments of such antibodies. The present invention also provides an αCTF and/or p3 peptide measurement method and a measurement kit using such antibodies or an antigen-binding fragment thereof.