RIBOFLAVIN FORMULATIONS FOR TRANS-EPITHELIAL CROSS-LINKING

摘要

The invention concerns preparations of riboflavin (vitamin B2) for use in the treatment of keratoconus with a variant of the non-invasive technique of corneal cross-linking, called trans-epithelial cross-linking, wherein the corneal epithelium is not removed and the preparation of riboflavin to be instilled on the cornea during the treatment is able to pass through the corneal epithelium. The preparations comprise, in aqueous solution, non-phosphorylated riboflavin and a boron compound selected from tetraborates, orthoborates and metaborates of alkali metals and alkaline earth metals, wherein the concentra¬ tion of riboflavin is between 0.01 and 2.0 % by weight and the weight ratio of the boron compound to riboflavin is from 1 :2.5 to 1:25.