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SINGLE-PARTICLE DETECTOR USING OPTICAL ANALYSIS, SINGLE-PARTICLE DETECTION METHOD USING SAME, AND COMPUTER PROGRAM FOR SINGLE-PARTICLE DETECTION
SINGLE-PARTICLE DETECTOR USING OPTICAL ANALYSIS, SINGLE-PARTICLE DETECTION METHOD USING SAME, AND COMPUTER PROGRAM FOR SINGLE-PARTICLE DETECTION
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机译:使用光学分析的单粒子检测器,使用相同的单粒子检测方法以及用于单粒子检测的计算机程序
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摘要
There is provided a single particle detection technique based on a scanning molecule counting method, enabling individual detection of a single particle using light measurement with a confocal microscope or multiphoton microscope, and quantitative observation of conditions or characteristics of the particle. The inventive technique of detecting a single particle in a sample solution is characterized by detecting light containing substantially constant background light from a light detection region with moving the position of the light detection region of the microscope in a sample solution to generate time series light intensity data; and detecting individually a light intensity reduction occurred when a single particle which does not emit light (or a particle whose emitting light intensity in a detected wavelength band is lower than the background light) enters in the light detection region in the time series light intensity data as a signal indicating the existence of each single particle.
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