Compounds and methods for inhibition of binding of ICAM-4 to platelet integrin alphaIIbbeta3

摘要

The present invention relates to compounds and methods for inhibition of binding of ICAM-4 to platelet integrin α_IIbβ₃.;The present invention also relates to a screening method and to a kit to detect or monitor in vitro the effect of a substance, drug or pharmaceutical agent on the ICAM-4/α_IIbβ₃ interaction in a biological sample, while simulating blood flow conditions existing in vivo.;It concerns in particular an anti-ICAM-4 antibody or a fragment thereof capable of blocking ICAM-4 binding to platelet integrin α_IIbβ₃, or an ICAM-4 mimetic peptide blocking ICAM-4 binding to platelet integrin α_IIbβ₃, or an anti-CD61 antibody or a fragment thereof capable of blocking ICAM-4 binding to platelet integrin α_IIbβ₃, for use in the treatment of a thrombotic disease, and for the preparation of pharmaceutical compositions for such treatment.