Active implantable medical device for treating heart failure with vagus nerve stimulation synchronised with the heart activity

摘要

This device comprises a burst generator pulse VNS stimulation of the vagus nerve, and means for heart rate analysis. Further comprising sequencing means, estimators with means for calculating at a given estimated cycle (R _prev) of the temporal position of the R wave of the next cycle, and means for setting the time (T _VNS) for the application of the burst of VNS pulses as a time corresponding to the estimated (R _prev), early a period of advance (Δ _VNS) predetermined. VNS therapy is delivered and in a non-vulnerable period near the end of the period of natural ventricular escape.