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Dual SPECT/MRI contrast agent and a process for the preparation thereof
Dual SPECT/MRI contrast agent and a process for the preparation thereof
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机译:SPECT / MRI双重造影剂及其制备方法
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摘要
PURPOSE: A compound which contains radioactive isotopes and paramagnetic elements and is used as a single photon emission computed tomography/magnetic resonance imaging (SPECT/MRI) dual contrast agent is provided to be used as a contrast agent for MRI and a nuclear medical imaging instrument without toxicity to human body and to effectively diagnose cancer. CONSTITUTION: A compound is denoted by chemical formula 1. The compound has a structure of chemical formula 1a. A method for preparing the compound comprises the steps of: reacting a compound of chemical formula 3 with a compound of chemical formula 4; and labeling a meta site of tyrosine of Arg-Gly-Asp (RGD) with iodine. A gadolinium precursor is Gd (III)X_3. A SPECT contrast agent contains the compound. A SPECT/MRI dual contrast agent contains the compound. [Reference numerals] (AA,BB) Ligand
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