CRYSTAL STRUCTURE OF MODIFIED EPRS PROTEIN AND CRYSTALLIZATION METHOD THEREOF

摘要

The present invention relates to a crystal structure of modified EPR protein and a crystallization method thereof and, more specifically, to a method which overexpresses the modified EPR protein where 1000 number of amino acids are removed from the N end portion of bifunctional glutamate/proline tRNA synthetase (EPRS) protein derived from human and refines and crystallizes the protein, and a crystal structure analyzed thereby. Therefore, the present invention provides the crystal structure and crystallization method of modified EPR protein having an amino acid of sequence number 1 including a PRS protein domain portion of the EPRS protein derived from human and can be used for inhibitor development.;COPYRIGHT KIPO 2014