THE ACTIVE COMPONENTS IN THE EXTRACT OF RHUS VERNICIFLUA BARK THAT ARE EFFECTIVE IN TREATING OR IMPROVING CONTACT DERMATITIS SYMPTOMS.

摘要

In the present invention, it has identified that there is anti-inflammatory effect to be induced through 2,4-dinitroflurorobenzene (DNFB) using inflammation in mouse and be had activated macrophage for that Rhus verniciflua bark. Therefore, there is the property that Rhus verniciflua barks reduce that vasopermeability increases these dermatitis apparent histology modification corium and epidermis to reduce the ear tissue for extending ear tissue and above-mentioned hyperkeratinization. It, which has, has had been acknowledged that wherein the implantation of Rhus verniciflua bark extracts passes through Toluidine blue staining for mast cell activity reduction goup. The Rhus verniciflua bark extracts be substantially reduced (iNOS) and cyclooxygenase 2 expression inducible nitric oxide synthase (COX-2) activation macrophage during translation the step of. In addition, production neoplasm necrosis factor (TNF-a) and interleukin 6 (IL-6) significantly decrease the macrophage activated when Rhus verniciflua bark extracts. The result indicates that wireless control iNOS, COX-2, proinflammatory cytokine can be expressed through NFkB signal transduction paths. In short, Rhus verniciflua bark extracts can differently be used as pharmaceutical composition and healthy functions food treatment dermatitis (seborrheid, idiocrasy contact dermatitis). ;The 2014 of copyright KIPO submissions