RAGE PROTEIN-BETA AMYLOID INTERACTION INHIBITOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH BETA AMYLOID ACCUMULATION CONTAINING THE SAME AS AN ACTIVE INGREDIENT

摘要

The present invention relates to a RAGE protein-beta amyloid interaction inhibitor, and a pharmaceutical composition for preventing or treating diseases associated with beta amyloid accumulation containing the same as an active ingredient. According to the present invention, RAGE protein V-domain-derived peptides and peptides, compounds or antibodies targeting the same have antagonism to RAGE protein, thereby being effectively used as a pharmaceutical composition for preventing or treating diseases induced by beta amyloid accumulation such as dementia, Alzheimers disease, Downs syndrome, amyloid angiopathy, amyloid cardiomyopathy, cerebral amyloid angiopathy, systemic amyloid disease, amyloid-associated amyloidosis (AA amyloidosis), amyloid-light chain amyloidosis (AL amyloidosis), etc. An RAGE protein and beta-amyloid interaction region confirmed in the present invention can be effectively used even in a method for screening a RAGE protein beta-amyloid inhibitor.