ACTIVE INGREDIENT DELIVERY SYSTEM FOR EXTENDING IN-VIVO HALF-LIFE OF ACTIVE INGREDIENT

摘要

Disclosed is an active ingredient delivery system for extending an in-vivo half-line of an active ingredient. The active ingredient delivery system comprises carrier peptide and the conjugate of the active ingredient. The conjugate has a serum half-line which is extended compared to the peculiar serum half-line of the active ingredient, the carrier peptide is a peptide bonded to albumin in blood in order to extend the serum half-line of the active ingredient. The carrier peptide is a peptide including sequence number 1, a peptide having a sequence homogeny of 80% or more with the peptide sequence, or a fragment of the same. The peptide having a sequence homogeny of 80% or more and the fragment may have a serum albumin bonding function of the sequence number 1 peptide. Using the techniques disclosed in the present invention, an in-vivo half-line of an active ingredient can be extended, and the administered amount and the number of administrations of the active ingredient can be reduced, so that the effects of the active ingredient can be improved.;COPYRIGHT KIPO 2014