NOVEL HETEROARYL CARBOXAMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING RAGE RECEPTOR-RELATED DISEASES

摘要

The present invention relates to a novel heteroaryl carboxamide derivative or pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition containing the same for preventing or treating RAGE receptor- or acetylcholineesterase activity-related diseases. The heteroaryl carboxamide derivative compound of the present invention has an antagonistic action on the RAGE receptor, thereby inhibiting beta-amyloid, which damages nerve cells, from migrating to the brain through binding to the RAGE receptor, thus dominantly inhibiting the formation of plaques due to excessive accumulation of beta-amyloid. Further, the heteroaryl carboxamide derivative compound of the present invention has an excellent effect of inhibiting acetylcholinesterase degrading acetylcholine, which is an important chemical material in a memory function, and thus can be useful to prevent or treat RAGE receptor- or acetylcholineesterase activity-related diseases, such as Alzheimer′s disease, cerebrovascular dementia, dementia due to head injury, multiinfarct dementia, dementia including Alzheimer′s disease and multiinfarct dementia mixed dementia or alcoholic dementia, Pick′s disease, Creutzfeldt-jakob disease, hypothyrodism, Parkinson′s disease due to head injury, and Huntington′s disease.;COPYRIGHT KIPO 2014