CROSSLINKED PEG HYDROGELS WITH DEGRADABLE PHOSPHAMIDE LINKERS AND THE METHOD FOR PRODUCING THEM

摘要

The present invention relates to a PEG hydrogel cross-linked by a biocompatible and biodegradable phosphamide linker and a method for preparing the same. Further, the present invention relates to a drug delivery system comprising the hydrogel and a pharmaceutically active component sealed in the hydrogel, and a method for manufacturing the same. Specifically, the hydrogel of the present invention is cross-linked according to nucleophilic substitution reaction of a glycidyl group of a prepolymer in which epichlorohydrin is introduced to the terminal of PEG (epichlorohydrin-modified PEG: EMP) and an amide group of phosphonyl amide.