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REDUCTION OF THE CONTENT OF PROTEIN CONTAMINANTS IN COMPOSITIONS COMPRISING A VITAMIN K-DEPENDENT PROTEIN OF INTEREST
REDUCTION OF THE CONTENT OF PROTEIN CONTAMINANTS IN COMPOSITIONS COMPRISING A VITAMIN K-DEPENDENT PROTEIN OF INTEREST
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机译:减少含有维生素K依赖性蛋白质的组合物中蛋白质污染物的含量
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摘要
The present invention relates to Vitamin K-dependent protein compositions having a very low, or negligible, content of protein contaminants. The present invention also relates to method applicable in the preparation of such Vitamin K-dependent protein compositions. Such methods may either be used alone or in sequential combination with the purpose of reducing the relative content of protein contaminants. The present invention is particularly relevant in the preparation of compositions of coagulation factors selected from Factor X polypeptides (FX/FXa), Factor IX polypeptides (FIX/FIXa), Factor VII polypeptides (FVII/FVIIa), and the anticoagulant Protein C, in particular Factor VII polypeptides.
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