Complex of hydrophilic photosensitizer and biocompatible polymer for useful photodynamic diagnosis or therapy and process of preparation thereof

摘要

The invention doedoe combined with hydrophilic relates to an optical sensitizer and a composite and a method for producing a biocompatible polymer, and I more specifically a biocompatible polymer and a hydrophilic photosensitizer ionic bond to be useful in photodynamic diagnosis or therapy, relates to photodynamic diagnosis or therapy, and a method of manufacturing composite configured for the perimeter of the hydrophilic to the surrounding light sensitizer is a biocompatible polymer. Complex according to the invention is ionized in water due to the electric charge by (a charge opposite to the charge, which has the polymer) a hydrophilic photo-charges of sensitizers with a biocompatible polymer having a charge and combined with the surface is internalized into tumor cells difficult hydrophilic to make excellent the accumulation of the optical sensitizer, is effective to kill the near-infrared irradiation during cancer greatly increases, as well as complexes that remain stable in the blood circulation process thereby does not indicate the cytotoxicity to normal cells vivo stability even superior effect the so can be useful in the diagnosis or treatment of disease using a photodynamic. ;