A cosmetic composition for anti-atopic skin desease comprising mitol and fucoidan mixture as an efficient component isolated from Ecklonia cava

摘要

PURPOSE: A composition containing Ecklonia cava-derived mitol and fucoidan and an external use skin formulation are provided to ensure an anti-inflammatory effect and to treat atopic dermatitis. CONSTITUTION: A composition with an anti-inflammatory effect contains 0.3 wt% of Ecklonia cava-derived mitol and 0.5-2 wt% of fucoidan. The mitol contains polyphenol derived from Ecklonia cava as an active ingredient. A method for preparing fucoidan comprises: a step of drying Ecklonia cava and extracting Ecklonia cava with 80% ethyl alcohol at room temperature for 12 hours; a step of centrifuging the extract and collect pellet; a step of mixing the pellet with 80% ethyl alcohol and stirring at room temperature for 12 hours; a step of centrifuging and collecting pellet; a step of removing pigment, lipid, and low molecular proteins using acetone and drying to prepare Ecklonia cava powder; a step of adding distilled water to the Ecklonia cava powder and extracting at 60 Deg.C. for 2 hours, centrifuging, and collecting supernatant; a step of adding CaCl_2 to supernatant and incubating at 4 Deg.C. for 18 hours; a step of centrifuging and collecting supernatant; and a step of concentrating the supernatant and adding ethyl alcohol.