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Novel Peptide having Antimicrobial Activity and Anti-inflammatory Activity

机译:具有抗菌活性和抗炎活性的新型肽

摘要

The present invention is low cytotoxicity , indicating a broad range of antimicrobial activity and anti-inflammatory activity , and mass production is easy and , to the excellent stability of the peptide , and more particularly, to for peptide characterized by containing arginine and histidine derivatives of formula 1 . The invention also relates to pharmaceutical compositions containing them and method of the histidine derivative with the peptide for the peptide produced . [ Formula 1] Where R = - (CH 2 ) n -CH3, - (CH 2 ) n -Ph or ( CH 2 ) n and -Cyclohexyl group , n = an integer from 1 to 7 . ;
机译:本发明的细胞毒性低,表明其广泛的抗微生物活性和抗炎活性,并且易于批量生产,并且对肽的优异稳定性特别是对于特征在于含有精氨酸和组氨酸衍生物的肽而言。公式1 。本发明还涉及含有它们的药物组合物以及组氨酸衍生物与所产生的肽的肽的方法。 [公式1]其中R =-(CH 2 n -CH3,-(CH 2 n -Ph或(CH 2 n和-环己基,n = 1至7的整数。 ;

著录项

  • 公开/公告号KR101381285B1

    专利类型

  • 公开/公告日2014-04-04

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR20120100762

  • 发明设计人 방정규;

    申请日2012-09-12

  • 分类号C07K5/06;C07K5/08;A61K38/05;A61P31/04;

  • 国家 KR

  • 入库时间 2022-08-21 15:41:12

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