A new preparation method of 1-1amp;rsquo;-(Carboxymethyl)cyclopropane methyldisulfanylmethylcyclopropaneacetic acid and it's derivatives

摘要

The present invention relates to a novel method for preparing 1-(1'-(carboxymethyl)cyclopropane methyl disulfonyl methyl)cyclopropane acetic acid and derivatives thereof which are precursors of 1-(mercaptomethyl)cyclopropane acetic acid, an important material for the synthesis of a pharmaceutical - especially Montelukast which is an antiasthmatic - in an industrially efficient way. The present invention provides a novel method for preparing 1-(1'-(carboxymethyl)cyclopropane methyl disulfonyl methyl)cyclopropane acetic acid and derivatives thereof characterized by reacting disodium disulfide salt with cyclopropane acetic acid derivatives appropriate for substitution by a mercapto group.