首页> 外国专利> 18-METHYL-19-NOR-ANDROST-4-EN-17,17-SPIROETHER (18-METHYL-19-NOR-20-SPIROX-4-EN-3-ONE) AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME

18-METHYL-19-NOR-ANDROST-4-EN-17,17-SPIROETHER (18-METHYL-19-NOR-20-SPIROX-4-EN-3-ONE) AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME

机译:18-甲基-19-NOR-ANDROST-4-EN-17,17-螺旋剂(18-甲基-19-NOR-20-SPIROX-4-EN-3-ONE)和包含相同成分的药物制剂

摘要

The present invention describes the novel 18-methyl-19-norandrost-4-ene 17,17-spiro ethers of the general formula I in which Z is an oxygen atom, two hydrogen atoms, a group NOR or NNHSO2R, where R is a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms, R4 is a hydrogen atom, a halogen atom or a trifluoromethyl group, and R6 and/or R7 may have or configuration, and R6 and R7 are independently of one another a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms or a straight- or branched-chain alkenyl group having 2 to 4 or 3 to 4 carbon atoms or a saturated cycloalkyl group having 3 to 5 carbon atoms or together are a methylene group or a double bond. The novel compounds have progestational and antimineralocorticoid activity.
机译:本发明描述了通式I的新颖的18-甲基-19-壬二茂-4-烯17,17-螺醚,其中Z是氧原子,两个氢原子,基团NOR或NHSO 2 R,其中R是A。氢原子或具有1至4或3至4个碳原子的直链或支链烷基,R 4是氢原子,卤素原子或三氟甲基,并且R 6和/或R 7可以具有或构型,并且R 6 R 1和R 7彼此独立地是氢原子或具有1至4或3至4个碳原子的直链或支链烷基或具有2至4或3至4个碳原子的直链或支链烯基或具有3至5个碳原子的饱和环烷基或一起为亚甲基或双键。新化合物具有孕激素和抗盐皮质激素的活性。

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