4-Thiopyrazole derivatives or pharmaceutically acceptable salts thereof process for the preparation thereof and pharmaceutical composition for the prevention and treatment of dyslipidemia containing the same as an active ingredient

摘要

The present invention is 4- thio -pyrazole derivative or a pharmaceutically acceptable salt thereof , a preparation method thereof , and it relates to a composition for preventing or treating hyperlipidemia or more lipids containing as an active ingredient , and serves to combine the 4- thio -pyrazole derivative represented by the general formula (1) niacin receptor GPR109A according to the invention to activate the receptor is superior , beta - sustaining because the activation of the array is less induced signaling pathways , while minimizing the flushing side effect may be useful for the prevention or treatment of lipid disorders , such as hypercholesterolemia hyperlipidemia [Formula 1] ( In Formula 1, R ¹ to R ⁴ is as defined herein ) ;