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TREATMENT USING REPROGRAMMED MATURE AND DIFFERENTIATED CELLS

机译:使用重编程的成熟细胞和分化细胞进行治疗

摘要

1. A method for updating tissue or cells of a patient cell line, comprising (i) obtaining committed progenitor cells of the first cell line; (ii) reprogramming committed progenitor cells to obtain reprogrammed cells; and (in) administering reprogrammed cells to a patient. 2. The method according to claim 1, in which the patient is ill with diseases or disorders selected from the group including bone marrow disorder, hematological conditions, aplastic anemia, beta-thalassemia, motor neuron disease, Parkinson's disease, spinal cord injury, muscular dystrophy, renal disease, disseminated sclerosis, clogging heart failure, hepatitis C virus, human immunodeficiency virus, head trauma, spinal cord injuries, lung disease, depression, nonobstructive azoospermia, andropause, menopause and infertility, rejuvenation, scleroderma ulcers, psoriasis, wrinkles, cirrhosis, autoimmune disease, baldness, retinitis, crystalline dystrophy / blindness, diabetes, cirrhosis of the liver and infertility. 3. The method of claim 1, wherein the reprogrammed cells are selected from the group consisting of pluripotent stem cells, hematopoietic stem cells, neuronal stem cells, epithelial stem cells, mesenchymal stem cells, endoderm and neuroectoderm stem cells, germ cells, extraembryonic stem cells, renal cells, alveolar epithelial cells, alveolar endoderm cells, neurons, ectoderm cells, islet cells, acinar cells, oocytes, sperm, hepatocytes, ke ratinocytes, melanocytes, osteocytes,
机译:1.一种更新患者细胞系的组织或细胞的方法,包括:(i)获得所述第一细胞系的定型祖细胞; (ii)重编程定型祖细胞以获得重编程的细胞; (in)对患者施用重编程的细胞。 2.根据权利要求1所述的方法,其中所述患者患有选自以下的疾病或病症:骨髓疾病,血液病,再生障碍性贫血,β-地中海贫血,运动神经元疾病,帕金森氏病,脊髓损伤,肌肉疾病营养不良,肾脏疾病,弥漫性硬化症,心力衰竭,丙型肝炎病毒,人类免疫缺陷病毒,头部外伤,脊髓损伤,肺部疾病,抑郁症,非阻塞性​​无精子症,更年期,更年期和不育,复兴,硬皮病,牛皮癣,皱纹,肝硬化,自身免疫性疾病,秃发,视网膜炎,晶体营养不良/失明,糖尿病,肝硬化和不育。 3.权利要求1的方法,其中所述重编程的细胞选自多能干细胞,造血干细胞,神经元干细胞,上皮干细胞,间充质干细胞,内胚层和神经外胚层干细胞,生殖细胞,胚外干细胞,肾细胞,肺泡上皮细胞,肺泡内胚层细胞,神经元,外胚层细胞,胰岛细胞,腺泡细胞,卵母细胞,精子,肝细胞,ke视网膜细胞,黑素细胞,骨细胞,

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