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Bioreactors, SYSTEMS AND METHODS FOR THE PRODUCTION AND / OR RESEARCH BODIES
Bioreactors, SYSTEMS AND METHODS FOR THE PRODUCTION AND / OR RESEARCH BODIES
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机译:用于生产和/或研究机构的生物反应器,系统和方法
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摘要
1. Bioreactor comprising;chamber;a first inlet and a first outlet fluidly connected to the chamber, and;a support structure for the body.;2. A kit comprising reagents for stimulating growth and reagents, where the reagents for growth are sufficient to support growth of the replacement body and the bioreactor stimulating reagents are suitable for the stimulation of one or more physiological responses organ-substitute.;3. A method for evaluating organ-substitute for transplantation, the method comprising:;definition ex vivo whether a body substitute one or more functional properties that are physiologically suitable for transplantation to a recipient.;4. A method of estimating a multicellular tissue, the method comprising:;definition ex vivo whether a multicellular tissue, one or more predetermined properties.;5. A method for determining whether a body substitute one or more functional or structural properties that are physiologically suitable for transplantation to a recipient, wherein the one or more structural properties assessed using magnetic resonance imaging, computerized axial tomography, positron emission tomography, X-ray analysis analysis or ultrasonic, or other non-penetrating via technology.;6. A method for evaluating organ-substitute, the method comprises determining the level of one or more physiological parameters of the recipient organ during organ growth ex vivo.;7. A method for evaluating organ-substitute ex vivoThe method comprises determining the level of functional properties of the replacement body with the radiopharmaceutical introduced into the body in the growth chamber.;8. A method for evaluating organ-substitute ex vivo, The method comprises determining the structural and / or functional properties of the replacement body using magnetic resonance imaging, computerized axial tomography, positron emission tomography, ultrasound or x-ray diffraction analysis or by analyzing other body penetrating in a growth chamber.;9. A method of assessing organ-substitute, the method comprises determining the substitute organ vascularization ex vivo.;10. A method for evaluating organ-substitute, the method comprises determining the blood flow within the organ-substitute ex vivo.;11. A method for evaluating organ-substitute, the method comprises determining the oxygen level within the organ-substitute ex vivo.;12. A method for evaluating organ-substitute, the method comprises determining the level of one or more physiological parameters in the set of recipient body points during organ growth ex vivo, and comparing the physiological parameter at each time point with a reference parameter for a given time, which is indicative of a healthy organ-substitute at the end of organ growth.;13. A method for determining a reference level of the physiological parameter at a predetermined time during body growth, which indicates the end of a healthy body organ growth, the method comprising for each of several artificial / synthetic / bodies made substitutes:;Analysis physiological parameter in a plurality of predetermined time points during body growth;;determination of body condition at the end of body growth; and;determining for each time physiological parameter levels that are associated with the levels of the healthy body of physiological parameters that are related to unhealthy body organ at the end of growth.;14. A method for determining the level of a physiological parameter which indicates the end of body growth.;15. A method for verifying that the entity is compatible with the substitute organ recipient before transplantation, the method comprising:;defining features of the first organ-substitute ex vivo.;determining a second aspect of the body of the recipient, and;transplantation of artificial / synthetic / manufactured organ recipient organ, if the first and second features are the same.;16. A method for verifying that the entity is compatible with the substitute organ recipient before transplantation, the method comprising:;labeled cells derived from the recipient's body by the first tag identifier,;growing body of substitute with the labeled cells to generate organ-substitute, a tagged first tag identifier,;confirmation that the first label identifier coincides with the organ recipient before the transplantation of artificial / synthetic / substitute-made body organ recipient.;17. A method for verifying that the entity is compatible with the substitute organ recipient before transplantation, the method comprising:;determining a first physical or chemical characteristics of the organ-substitute ex vivo.;determining a second physical or chemical features of the body of the recipient, and;transplantation of artificial / synthetic / organ-substitute produced organ recipient, if the first and second compatible physiological characteristics, wherein the first and second physiologic characteristics are non-immunological response.;18. The method of organ-substitute cultivation ex vivo, The method comprising:;growing body substitute in a growth chamber at at least a first condition during the first growth period and at a second growth condition for a second time period, wherein the first and second different growth condition.;19. A method for determining the state of at least one part of the examined tissue or organ, comprising:;the location of the infrared detector near the considered tissue or organ;;registering the infrared radiation emitted from the at least one part of a tissue or organ;;specific analysis of infrared radiation and generating data relating to at least one part of a tissue or organ; and;determining the status of at least one part of a tissue or organ, at least partly based on the generated data.;20 is installed on the head unit comprising:;at least two detectors that provide the possibility of orthogonal viewing;;optical observation system WYSIWYG (what you see on screen is what you get);;device with the AF function in real time;;image stabilization controller;;microscope with magnifying capacity of at least 10 ×, at least 15 ×, at least 20 ×, at least 50 ×, at least 100 ×, at least 250 ×, or at least 500 ×;;and Binocular Telescope.
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