5-OXO-5,8-DIHYDROPYRIDO 2,3-d PYRIMIDINE DERIVATIVES AS CAMKII KINASE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES

摘要

1. A compound according to general formula (I) in which: - A is CH or C (alkyl); X is CH, C (alkyl) or N; - R, R, R and R are the same or different, each independently from another means: • a hydrogen atom; • linear, branched or cyclic alkyl, possibly substituted one or more times: o by halogen atoms; o -OR; o -NRR '; o -CN; o -C (O) OR; o - C (O) NRR '; o -S (O) Ro -S (O) NRR'; where R, R ', R and p are as defined below • group -S (O) R, where p and R are as as defined below; • an —OR group, where R is the same as defined below; • a halogen atom; • a —N (R) C (O) R group, where (i) R and R are, independently of each other, an atom in a hydrogen or linear, branched or cyclic alkyl optionally substituted with one or more substituents selected from halogen atoms, —OR groups and —NRR ′ groups, or (ii) R and R, together with the atoms to which they are attached, form heterocycloalkyl to give lactam; • the group —N (R) —CH — C (O) NRR, where R and R together with the atoms to which they are attached form heterocycloalkyl to produce piperazinone, and where R is the same as defined below; • the group —C (O) NRR where R and R, together with the nitrogen atom to which they are bonded, form a heterocycloalkyl, • -TU group, where: - T means: o a single bond, o an alkylene group, linear or branched; o a group -C (O) -, o a group -S (O) -, where p is as defined below, or o a group -O- (CH) -, where n as defined below, wherein U is a heterocycle containing one or more heteroatoms selected from N, O and S (O), where p is as defined below, and said heterocycle is saturated, unsaturated or aromatic, possibly one doubly or repeatedly substituted by one, two or more substituents selected from: o —OR groups, where R is, as defined below, o gal atoms