BIOLOGICAL PRODUCTION graft NERVE TISSUE ENGINEERING METHODS AND THEIR APPLICATIONS

摘要

1. A multicellular structure comprising: multicellular region comprising a plurality of viable cells attached to each other to form an elongated graft to restore neural connections between the ends of a ruptured nerve; and a plurality of non-cellular channels extending longitudinally within transplantata.2. A multicellular structure according to claim 1, characterized in that the hollow channels noncellular partially filled with one or more non-cellular materials, completely filled with one or more non-cellular materials, or any combination of these is implemented sostoyaniy.3. A multicellular structure according to claim 1 or 2, characterized in that the living cells include cells selected from the group consisting of mesenchymal stem cells, bone marrow stem cells, the stem cells of the hair follicles, parietal neuroepithelial cells, fibroblasts, smooth muscle cells, Schwann cells and their sochetaniy.4. A multicellular structure according to claim 3, characterized in that from about 0.1% to about 20% of the total number of living cells in the multicell area are Schwann cells; from about 1% to about 15% of the total number of living cells in the multicell area are Schwann cells; from about 1% to about 10% of the total number of living cells in the multicell area are Schwann cells; from about 3% to about 10% of the total number of living cells in the multicell area are Schwann cells; or from about 5% to about 10% of the total number of living cells in the multicell area are Schwann kletkami.5.