A method for diagnosing glioblastoma multiforme with the aid of MRI and contrast agent for MRI OF RESEARCH

摘要

1. A method for diagnosing glioblastoma multiforme comprising MRI study before and after intravenous contrast medium, which is used as magnetic iron oxide nanoparticles stabilized with a biocompatible polymer, and conjugated monoclonal antibody to vascular endothelial growth factor having a hydrodynamic diameter less than 150 nm, wherein the MRI study performed in a mode as to obtain a weighted portion of the magnetic susceptibility of the test image, and conclusions about the presence ii glioblastoma multiforme make based on the comparison of MR images before and after administration of a contrast agent according areas reduce the brightness of the MR snimkah.2. A method according to claim 1, characterized in that after the administration of contrast agent MRI study performed for the contrast agent circulation time in krovi.3. A method according to claim 1, characterized in that after the administration of contrast agent MRI study carried out for a time sufficient for the accumulation of contrast agent in the tissue glioblastomy.4 multiforme. A method according to claim 1, characterized in that after the administration of contrast agent MRI study performed for the contrast agent circulation time in blood and for a time sufficient for accumulation of the contrast agent in the tissue glioblastomy.5 multiforme. A method according to claim 2, characterized in that the MRI is conducted for 15 minutes-4 chasov.6. A method according to claim 3, characterized in that the MRI study carried out for 6-72 chasov.7. A method according to claim 1, characterized in that the contrast agent is administered to a