APPLICATION OF SIGMA LIGANDS IN OPIOID-OPERATED HYPERALGESIA

摘要

1. Sigma receptor ligand for use in the prophylaxis and / or treatment of opioid-induced hyperalgesia associated with opioid therapy. The sigma receptor ligand for use according to claim 1, wherein said sigma receptor ligand is selected from the group consisting of a sigma receptor antagonist, preferably selected from a neutral antagonist, an inverse agonist, or a partial antagonist. The sigma receptor ligand of general formula (I) for use according to claim 1 or 2, wherein R is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted heterocyclylalkyl, —COR, —C (O) OR, —C (O) NRR, —CH = NR, —CN, —OR, —OC (O) R, -S (O) -R, -NRR, -NRC (O) R, -NO, -N = CR R and halogen; R is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted, aromatic or non-aromatic heterocyclyl, substituted or unsubstituted -COR, -C (O) OR, -C (O) NRR, -CH = NR, -CN, -OR, -OC (O) R, -S (O) -R, -NRR, -NRC (O ) R, -NO, -N = CRR and halogen; R and R are independently selected from the group consisting of hydrogen, substituted or unsubstituted lkila, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or