DERIVATIVES OF QUINOLINE, in particular 6, 7-Substituted 1 (2nd-chloroquinoline-3- IL) - 4 - DIMETHYLAMINO -2 (NAPHTHALENE-1- IL) - 1-phenyl-butan-2-, METHOD OF PREPARATION AND USE OF THE COMPOUND FOR PROCESSING INFECTIOUS DISEASES OF mycobacterial NATURE, IN PARTICULAR TUBERCULOSIS

摘要

1. quinoline derivatives, in particular 6,7-substituted 1- (2-chloroquinolin-3-yl) -4-dimethylamino-2- (naphthalene-1-yl) -1-phenylbutan-2-ols of general formula (I) : wherein R H, R + Roznachaet -O- (CH) -O-, where n = 1-2, which forms additional dioxane and 1,3-dioxolane rings or their pharmaceutically acceptable salts with acids, having antimycobacterial aktivnostyu.2 . A process for preparing compounds of formula (I) according to claim 1 by reacting a substituted 2-chloro-3-alkarilhinolinov and aryl ketones under metallating agentov.3. A method according to claim 2, characterized in that the metallating agent used litiya.4 diethylamide. Use of compounds according to claim 1 for the treatment of mycobacterial infections nature, in particular tuberculosis.