METHOD FOR DETERMINING NON-SMALL CELLS LUNG CANCER SENSITIVITY TO PREPARATIONS REACTIVATING PROTEIN p53

摘要

FIELD: medicine.;SUBSTANCE: invention refers to oncology and molecular biology. What is presented is a method for determining the non-small cells lung cancer sensitivity to the preparations reactivating protein p53, involving the recovery of RNA from samples, the synthesis of complementary DNA of the genes CDKN1A, BTG2 and E2F1 by reverse transcription and real-time polymerase chain reaction, and the determination of a relation of the amount of complementary DNA of the gene E2F1 to the amount of complementary DNA of the gene CDKN1A or the gene BTG2, wherein if observing the relation of E2F1/CDKN1A3 or E2F1/BTG21.5, the non-small cells lung cancer cells are considered to be sensitive to the preparations reactivating protein p53.;EFFECT: invention may be used in treating oncological diseases.;3 dwg, 3 tbl, 1 ex