CYCLOSPORINE DERIVATIVES FOR TREATING OPHTHALMIC AND SKIN DISEASES AND CONDITIONS

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to a compound selected from a group consisting of compounds presented by formula:; ;In the above formula, R₁ represents S-Alk-R, wherein Alk represents methylene, C₂-C₆ polymethylene bond or C₃-C₆ alkenylene bond, R represents -N=C(NR₃R₄)(NR₅R₆) or -NR₇[(NR₃R₄)C=NR₅], or -N=C(R₈)(NR₉R₁₀), wherein R₃-R₁₀ represents H, Alk, Ar or (CH₂)_nAr, wherein Ar represents an aryl group, and n represents an integer from 1 to 13, or R₃ and R₄, or R₄ and R₅, or R₅ and R₇, or R₃ and R₇, or R₉ and R₁₀, or R₈ and R₉ together can represent -(CH₂)_x-, wherein x represents an integer from 2 to 5, and R₂ is specified in a group consisting of hydroxyl, alkyl having from 1 to 7 carbon atoms, and substituted by alkyl hydroxyl having from 1 to 7 carbon atoms.;EFFECT: preparing new cyclosporine derivatives.;5 cl, 2 ex