COMPOUNDS PRODUCING STIMULATING EFFECT ON SUBTYPE B RECEPTOR OF PEROXISOME PROLIFERATION ACTIVATOR, METHOD OF OBTAINING AND APPLICATION THEREOF

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: described is a novel compound of formula I ; , ;where X and Y stand for O or S, R, R³, G¹- G³ stand for H or C_1-9alkyl; R¹ and R² is H or C_1-4alkyl; R⁴ is H or phenyl; G⁴- G⁶ and G⁸- G⁹ are H; G⁷ is trifluoromethyl, a pharmaceutical composition containing it, methods of obtaining, an initial compound in methods described and a method of obtaining the initial compound and application of the formula I compound for treatment or prevention of a disease by activation of receptor δ(PPARδ); the said disease represents metabolic syndrome, obesity, dyslipidemia, pathological glycemia, insulin resistance, senile dementia and tumours.;EFFECT: obtaining the formula I compounds for treatment or prevention of the disease by activation of receptor δ(PPARδ).;20 cl, 47 ex, 3 dwg, 5 tbl