FIELD: medicine.;SUBSTANCE: claimed invention relates to biotechnology and represents a polypeptide construction for treatment, prevention and relief of disorders, associated with an adhesion of platelets and platelet-mediated aggregation or its dysfunction, which includes one or more single-domain antibodies, aimed against the von Willebrand factor (vWF), and one or more single-domain antibodies aimed against serum albumen (SA). The invention also relates to nucleic acid, coding such polypeptide construction, to compositions, containing the said construction, and to its application for obtaining medications for prevention, treatment and relief of the said disorders.;EFFECT: claimed invention makes it possible to extend an assortment of medications for treatment, prevention and relief of disorders, associated with the platelet adhesion and platelet-associated aggregation or its dysfunction.;15 cl, 30 dwg, 32 tbl, 69 ex
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机译：具有血小板粘附和血小板介导的聚集或其功能障碍的多肽构造物，其包含一种或多种单域抗体，所述多肽构造物用于治疗，预防和缓解疾病，所述多肽构造物与血小板的粘附和血小板介导的聚集或其功能障碍有关。 ，针对von Willebrand因子（vWF），以及针对血清蛋白（SA）的一种或多种单域抗体。本发明还涉及编码这种多肽结构的核酸，涉及包含所述结构的组合物，及其在获得用于预防，治疗和减轻所述疾病的药物中的应用。与血小板粘附和血小板相关的聚集或其功能障碍有关的用于治疗，预防和缓解疾病的药物分类; 15 cl，30 dwg，32 tbl，69 ex
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