Producing metallic labeled compounds, involves providing first solution from first solvent comprising water and first non-aqueous solvent, and first acid and first metal dissolved in solvent

摘要

Producing metallic labeled compounds, comprises: (a) providing a first solution from a first solvent comprising 0-100 vol.% of water and 0-100 vol.% of a first non-aqueous solvent, and a first acid and a first metal dissolved in the solvent; (b) optionally providing a second solution of a second solvent comprising 0-100 vol.% of water and 0-100 vol.% of a second non-aqueous solvent, and a second acid and a second metal dissolved in the second solvent; and (C) providing a third solution of a third solvent comprising 0-100 vol.% of water and 0-100 vol.% of a third non-aqueous solvent. Producing metallic labeled compounds, comprises: (a) providing a first solution from a first solvent comprising 0-100 vol.% of water and 0-100 vol.% of a first non-aqueous solvent, and a first acid and a first metal dissolved in the solvent; (b) optionally providing a second solution of a second solvent comprising 0-100 vol.% of water and 0-100 vol.% of a second non-aqueous solvent, and a second acid and a second metal dissolved in the second solvent; (C) providing a third solution of a third solvent comprising 0-100 vol.% of water and 0-100 vol.% of a third non-aqueous solvent, and a conjugate of a ligand dissolved in the solvent and one or more biologically active molecule residues or transporter systems directly bounded to the ligand or via spacer groups; (D) mixing the first and third, and optionally second solution optionally with the addition of the first, third and/or second non-aqueous solvent to a reaction mixture, where the total amount of the first, third and/or second non-aqueous solvent is 0.1-100 vol.%; and (E) complexing the first metal and optionally the second metal with the conjugate.