Incretin receptor ligand polypeptide FC region fusion polypeptide and complex having modified FC effector function

摘要

An Fc region fusion polypeptide or Fc region complex comprising one to four incretin receptor ligand polypeptides and a variant human Fc region and its use as a medicament are reported herein, wherein the variant human Fc region comprises: Mutation of amino acid residue at position 329 and a different residue of at least one amino acid selected from the group comprising amino acid residues at positions 228, 233, 234, 235, 236, 237, 297, 318, 320, 322 and 331 With at least one further mutation to where the Fc region residues are numbered according to Kabat's EU index. [Selection] Figure 9a