In vitro diagnosis of invasive fungal infections by MALDI-TOF mass spectrometry

摘要

The present invention relates to an in vitro diagnostic method for invasive fungal infections by MALDI-TOF mass spectrometry. The present invention is: a liquid biological sample derived from a mammal, in particular a protein and / or lipid and / or salt and / or a polysaccharide capable of forming a complex with said protein and / or lipid and / or salt And / or providing a biological sample containing oligosaccharides and / or monosaccharides, treating the sample with a biological fluid to extract the polysaccharides and / or oligosaccharides and / or monosaccharides, Determining the presence or absence of at least one compound of interest from fungal microorganisms in at least one of oligosaccharides and / or monosaccharides using MALDI-TOF mass spectrometry; If the compound of interest is present, inferring that the mammal has an invasive fungal infection.