SPHINGOSINE MONOPHOSPHATE RECEPTOR REGULATOR AND USE FOR THERAPY OF MUSCLE INFLAMMATION

摘要

PROBLEM TO BE SOLVED: To provide a medicine for prevention, inhibition or therapy of an inflammatory symptom selected from polymyositis, dermatomyositis and nerve-muscle diseases, for example muscular dystrophy and inclusion body myositis.SOLUTION: A therapeutic drug of muscle inflammation or inflammatory myopathy consists of a compound exemplified by 1-{4-[1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl}-azetidine-3-carboxylic acid (compound A), and an N-oxide derivative thereof, or a prodrug thereof, a mixture of individual isomers and isomer thereof, and a pharmaceutically acceptable salt or prodrug thereof, and the like.