Methods and compositions for hair cell and / or support cell regeneration

摘要

Methods and compositions are provided that allow inner ear cells (eg, cochlea and ovarian hair cells) to re-enter and propagate in the cell cycle. More particularly, the present invention increases c-myc activity and / or Notch activity to induce cell cycle re-entry and proliferation of cochlear or ovarian sac hair cells and / or cochlear or ovarian sac support cells Relates to the use of drugs. Methods and compositions are used to promote the growth of hair cells and / or support cells to cause hearing loss and suffering subjects, or at risk of or suffering from vestibular dysfunction The subject can be treated.