Dihydropyrimidin-2 (1H) -ones and dihydropyrimidine-2 (1H) -thiones as inhibitors of sodium iodide symporter

摘要

The present invention relates to novel dihydropyrimidin-2 (1H) -ones and dihydropyrimidine-2 (1H) -thiones of formula (Ia): The invention also relates to the use of said compounds as medicaments, in particular as inhibitors of sodium iodide symporter (NIS) and as an attenuator of the transport and / or accumulation of iodine into NIS-expressing cells. The invention also relates to a pharmaceutical composition comprising as active ingredient at least one compound of formula (Ia). [Selection figure] None