NON-HUMAN MAMMAL AS ARTERIOSCLEROSIS OBLITERANS MODEL ANIMAL, EMACIATION RESEARCH MODEL ANIMAL AND GENERALIZED AMYLOIDOSIS MODEL ANIMAL

摘要

PROBLEM TO BE SOLVED: To provide a disease model animal of at least one from a disease group consisting of an arteriosclerosis obliterans model animal, a diet pill research model animal, and a generalized amyloidosis.SOLUTION: A non-human mammal is characterized by causing at least one disease from a disease group by inducing endogeny IL-1 and/or IL-1. It is preferable that the non-human mammal may have (1) a transgenic non-human mammal having a recombinant DNA connecting the above type caspases gene 1 to the downstream of a gene promoter expressed skin-specifically, and continually causing dermatitis, or (2) a transgenic non-human mammal having a parathyroid Hormone gene leader sequence and the recombinant DNA connecting IL-18 gene on the downstream of the gene promoter expressed skin-specifically, and continuously secreting mature IL-18 in blood and causing the dermatitis continuously.