Synthesis of Jiamidogeru agent by using the amino acid N- carboxy anhydride

摘要

The present invention provides a process for the synthesis of a compound according to formula I, comprising the following steps: a) reacting an N-carboxy anhydride according to formula II and an N-carboxy anhydride according to formula III with a diamine according to formula IV; and b) adding an acid to the reaction to adjust the pH value of the reaction to 7, wherein L is a C2-C20-alkyl group, C6-C20-aryl group, or C7-C20- Represents an alkylaryl group, and R1 and R2 may be the same or different, and are a hydrogen atom, a C1-C6-alkyl group, a C1-C4-hydroxyalkyl group, a C1-C4-thioether group, a C6-C20- An aryl group, a C7-C20-alkylaryl group, a C7-C20-alkylhydroxyaryl group, a C4-C20-alkylheteroaryl group having 1-4 heteroatoms, or a C1-C4-a Kirukarubokishi component represents the (acid, or may be an amide, or C1~C6- alkyl group or C7~C20- alkylaryl group may be esterified), relates to the aforementioned method.