The present invention, in continuous clonotypic profiles of individuals, by measuring the absence of a change and / or a change in a particular group of related chronograph type (referred to as "clan" herein), follicle It relates to a method for prognosis in the individual transformation from sexual lymphoma to diffuse large B-cell lymphoma (DLBCL). Clan, may occur from a single lymphocyte precursor to generate a lot of relevant lymphocyte descendants, each lymphocyte offspring, somatic mutation, for example base substitutions, inversions, and as a result the common V (D ) J reasons such as the relevant reconstructed bring the use of gene segments, and are held and / or express a slightly different immunoglobulin receptors. It is more likely that the transformation from follicular lymphoma to DLBCL, in consecutive clonotypic profile, is correlated with the fact that the clan is to survive in does not occur over time diversification to clonotypic membership of Klang is there.
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