Magnetic nanoparticles dispersant, their preparation and diagnostic and therapeutic applications

摘要

The present invention relates to a magnetic particle dispersant comprising a coated iron oxide single crystal and / or polycrystalline single nanoparticle, which has improved heating characteristics in an alternating magnetic field and improved non-linear magnetization behavior, and a nanoparticle aggregate thereof (Multi-core particles). When measured on a magnetic particle spectrometer (MPS), the particle dispersant exhibits a clear overtone structure, especially at harmonics. This is many times higher than all previously known particle systems. Therefore, this dispersant is particularly effective for uses such as MPI (magnetic particle imaging diagnosis). In addition, novel particle dispersants are useful for the treatment of iron deficiency anemia and therapeutic hyperthermia (especially passive hyperthermia in parts of the body), or for cell tracking and magnetic resonance imaging (MRI). Is suitable. Therefore, the diagnostic and therapeutic uses of dispersants and pharmaceutical compositions relating to diagnostic or therapeutic subjects containing these dispersants are also an object of the present invention. [Selection figure] None