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Treatment of tinnitus by regulation of chloride ion symporter NKCC1 in the auditory system

机译：通过调节听觉系统中氯离子转运体NKCC1治疗耳鸣

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摘要

The present invention relates to the treatment or prevention of tinnitus. More precisely, the present invention relates to a compound that modulates the chloride ion cotransporter NKCC1 (chloride ion cotransporter modulator) for use in the treatment of tinnitus. Furthermore, the present invention provides a pharmaceutical composition containing such an NKCC1 chloride ion cotransporter modulator as an active agent, a method for treating or preventing tinnitus by administering such a chloride ion cotransporter modulator, and chloride ion. The present invention relates to screening methods for identifying and characterizing compounds capable of modulating the cotransporter NKCC1.

机译：本发明涉及耳鸣的治疗或预防。更确切地，本发明涉及调节用于治疗耳鸣的氯离子共转运蛋白NKCC1（氯离子共转运调节剂）的化合物。此外，本发明提供了包含这样的NKCC1氯离子辅助转运蛋白调节剂作为活性剂的药物组合物，通过给予这种氯离子辅助转运蛋白调节剂来治疗或预防耳鸣的方法以及氯离子。本发明涉及用于鉴定和表征能够调节共转运蛋白NKCC1的化合物的筛选方法。

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公开/公告号JP2015505844A

专利类型
公开/公告日2015-02-26

原文格式PDF
申请/专利权人オトラーヌムアーゲー;
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申请/专利号JP20140546328
发明设计人クニッパー;マルリース;リュッティガー;ルーカス;
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申请日2011-12-12
分类号A61K45;A61P27/16;A61P43;A61K31/192;A61K31/341;A61K31/402;A61K31/41;A61K31/4409;A61K31/549;A61K31/635;A61K31/4035;A61K31/404;A61K31/517;A61K31/433;A61K31/382;A61K31/542;A61K31/18;A61K39/395;A61K48;A61K31/713;A61K31/7105;A61K38;A61K31/40;A61K31/553;A61K9/06;A61K9/08;A61K47/36;A61K47/42;A61K47/34;A61K47/26;A61K47/14;G01N33/15;G01N33/50;
国家 JP
入库时间 2022-08-21 15:31:11

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