Amorphous pharmaceutical fine particles and a method of manufacturing the same are produced by pulsed laser ablation in liquid

摘要

The present disclosure relates to a method of using a laser in a liquid to produce a solution of an amorphous solid pharmaceutical compound microparticle, a solution of an amorphous pharmaceutical agent microparticle produced using the method, and the method Related to the fine particles produced. By using a target solidified via a phase transition method that converts the initial crystal structure to an amorphous solid, technical difficulties in handling a target compressed by hydraulic pressure are overcome. Amorphous solid pharmaceutical compound microparticles that improve the bioavailability and solubility of the pharmaceutical compound are produced by an ablation method using a laser. This improvement occurs as a result of the combination of an irregular crystal structure and an enlarged relative surface area due to particle size reduction. The method using a laser can be performed using an ultrashort pulse laser system or a UV-ns (ultraviolet nanosecond) laser. The results obtained with ultrashort near IR (infrared) lasers and UV-ns lasers demonstrate the formation of amorphous solid curcumin microparticles.