首页>
外国专利>
Their use as a vehicle to specifically deliver the compound to the hydrophobic modified preS-derived peptides and liver of hepatitis B virus (HBV)
Their use as a vehicle to specifically deliver the compound to the hydrophobic modified preS-derived peptides and liver of hepatitis B virus (HBV)
展开▼
机译:它们用作将化合物特异性递送至疏水修饰的preS衍生肽和乙型肝炎病毒(HBV)肝脏的载体
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to hydrophobic modified preS-derived peptides of hepatitis B virus (HBV) which are versatile vehicles for the specific delivery of compounds to the liver, preferably to hepatocytes, in vitro as well as in vivo. Any kind of compound, but in particular drugs, such as interferons, viral reverse transcriptase inhibitors or core assembly inhibitors, and/or labels can be specifically targeted to the liver and so be enriched in the liver. This liver targeting can further be used for the targeted diagnosis, prevention and/or treatment of liver diseases or disorders, such as hepatitis, malaria, hepatocellular carcinoma (HCC), as well as for the prevention of HAV, HBV, HCV and/or HDV infection. The present invention relates to pharmaceutical compositions comprising said hydrophobic modified preS-derived peptide(s) and the compound(s) to be specifically delivered to the liver. The present invention furthermore relates to a method for the combined treatment of a liver disease and the prevention of HAV, HBV, HCV and/or HDV infection. The present invention relates also to the use of the preS-derived peptides in gene therapy and the delivery of immunogenic epitopes for hepatocyte-mediated antigen presentation to activate liver-directed immunological responses.
展开▼