Process for the preparation of the iron oxide nanoparticles coated with hydrophilic material, and magnetic resonance imaging contrast agent comprising iron oxide nanoparticles

摘要

This invention, coat doing the iron oxide nano grain where magnetism improves by the fact that annealing it does with the hydrophilic material making use of the salt, the manner which prepares the living body compatibility iron oxide nano grain, and the magnetic resonance image which includes the iron oxide nano grain which is prepared because of this (magnetic resonance imaging and MRI) regards the contrast medium. Although the inside carboxymethyl dextran of the hydrophilic material (Carboxymethyl dextran, CM - dextran), is stabilized the iron oxide nano grain which was heat-treated, at the same time plays the image effect it is most efficient. Choice figure Drawing 1