Method for the treatment and prevention of methylnaltrexone oral compositions opioid-induced constipation with

摘要

Described herein are methods for treating or preventing opioid-induced constipation by administration of an oral composition of methylnaltrexone. The method is suitable for identifying such subjects that are particularly sensitive to such treatment and for treating or preventing opioid-induced constipation, and for optimizing such oral compositions that minimize the occurrence of adverse events associated with such treatment. Based at least in part on dose identification. [Selection] Figure 1