PUFA polyketide synthase systems and methods for their use

摘要

The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKA) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to methods of making and using such system for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.