Switching fluorescent nanoparticle probes and fluorescent molecular imaging method using it .

摘要

(Fluorescent dye is quenched nanoparticle preparation, ability to fluoresce in imaging time) to provide imaging for fluorescent nanoparticles novel probe having a switching function. A fluorescent nanoparticle probe comprising a fluorescent dye that has been enclosed and its molecular assembly composed of amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain, (a) hydrophilic block chain, sarcosine is intended to include hydrophilic essential structural units of units selected from alkylene oxide units and units, (b) hydrophobic block chain, hydrophobic essential structural units of units selected from the group consisting of hydroxy acid units and amino acid units It is intended to include the following formula (c) fluorescent dye (I): [Formula 1] a cyanine compound represented by the fluorescent dye is more encapsulated molecules per molecular assembly, switching fluorescent nanoparticle probes.