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EXTRACELLULAR MATRIX PROTEINS FROM HAEMOPHILUS INFLUENZAE BIOFILMS: TARGETS FOR THERAPEUTIC OR DIAGNOSTIC USE

机译：流感嗜血杆菌生物膜的细胞外基质蛋白：治疗或诊断用途的目标

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摘要

A method of identifying a biofilm that includes non-typeable Haemophilus influenza (NTHi) including a step of screening a sample for the presence of one or more biofilm-specific proteins that are expressed by NTHi. In some cases, an NTHi biofilm-related disease in a subject is diagnosed. Also disclosed are protein microarrays for screening biofilm-specific proteins in a sample, formulations comprising one or more biofilm-specific proteins or fragments thereof, and methods for inducing an immune response in a patient against a biofilm-related infection.

机译：一种鉴定包括不可分型的嗜血杆菌流感（NTHi）的生物膜的方法，该方法包括筛选样品中是否存在由NTHi表达的一种或多种生物膜特异性蛋白的步骤。在某些情况下，诊断出受试者中与NTHi生物膜相关的疾病。还公开了用于筛选样品中生物膜特异性蛋白的蛋白质微阵列，包含一种或多种生物膜特异性蛋白或其片段的制剂，以及在患者体内诱导针对生物膜相关感染的免疫应答的方法。 展开▼

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公开/公告号US2015293092A1

专利类型

公开/公告日2015-10-15

原文格式PDF

申请/专利权人 OAK CREST INSTITUTE OF SCIENCE;
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申请/专利号US201514749504

发明设计人 PAUL WEBSTER;SIVA WU;JAMES KERWIN;
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申请日2015-06-24

分类号G01N33/569;A61K39/102;C07K14/285;

国家 US

入库时间 2022-08-21 15:27:30

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1. 细胞外基质蛋白1及其调节剂在制备过敏性疾病诊断或治疗药物中的应用 [P] . 中国专利： CN102552910B . 2014.06.04

2. 细胞外基质蛋白1及其调节剂在制备过敏性疾病诊断或治疗药物中的应用 [P] . 中国专利： CN102552910A . 2012-07-11

3. EXTRACELLULAR MATRIX PROTEINS FROM HAEMOPHILUS INFLUENZAE BIOFILMS: TARGETS FOR THERAPEUTIC OR DIAGNOSTIC USE [P] . 美国专利： US2012276145A1 . 2012-11-01

机译：流感嗜血杆菌生物膜的细胞外基质蛋白：治疗或诊断用途的目标

4. The mutant protein isolated and purified hin47 Haemophilus influenzae, molu00c9cula quimu00c9rica, molu00c9cula acid nuclu00c9ico, plasmu00cddeo recombinant, cu00c9lula E.Coli transformed composition imunogu00canica, process to determine the presence of antibodies specifically reactive with the hin47 protein in a sample, a process to determine the presence of hin47 protein in a sample and diagnostic kit for determining the presence of antibodies in. Oyster specifically reactive with the protein hin47. [P] . BR9506272B8 . 2014-08-05

机译：分离和纯化的突变蛋白hin47流感嗜血杆菌，mol核酸，mol重组质粒，c。oli大肠杆菌转化组合物imunog u00canica，专门用于确定抗体的存在与样品中的hin47蛋白反应的方法，确定样品中hin47蛋白的存在的方法以及确定试剂盒中抗体存在的诊断试剂盒。与该蛋白hin47特异性反应的牡蛎。

5. A polynucleotide that encodes a Protein of the Extracellular Matrix, the use of the polynucleotide, a recombinant expression vector, a Protein of the Extracellular Matrix, the use of the polypeptide and Diagnostic, Pharmaceutical compositions comprising the polypeptide, a Transfected Cell, a [P] . AR033829A1 . 2004-01-07

机译：编码细胞外基质蛋白的多核苷酸，该多核苷酸的用途，重组表达载体，细胞外基质的蛋白，该多肽的用途和包含该多肽的诊断，药物组合物，转染的细胞，

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