首页>
外国专利>
OPTICALLY ACTIVE AXIALLY CHIRAL ALPHA-ALLENIC ALCOHOL, SYNTHESIS METHOD AND USE THEREOF
OPTICALLY ACTIVE AXIALLY CHIRAL ALPHA-ALLENIC ALCOHOL, SYNTHESIS METHOD AND USE THEREOF
展开▼
机译:光学活性轴向手性α-丙二烯醇,合成方法及其用途
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to an optically active axially chiral α-allenic alcohol, a synthetic method and use thereof. A method of preparing a high optically active chiral α-allenic alcohol by using propargyl alcohol, aldehyde and chiral α,α-diphenyl-L-prolinol under the protection of tert-butyldimethylsilyl with a mediator zinc bromide. The axially chiral α-allenic alcohol has the structural formula (I). The method of the present invention has the following advantages: the synthesis route is short, operations are simple, raw materials are readily available, separation and purification are convenient, the substrate has high generality, the total yield is high, and enantioselectivity and diastereoselectivity are high. The high optically active axially chiral α-allenic alcohol synthesized by adopting the method of the present invention can conveniently synthesize 2,5-dihydrofuran compounds having central chirality via complete chirality transfer, and at the same time can further be used to synthesize axially chiral allenic amine and allenic malonate compounds without reacemization.; 展开▼