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GANGLIOSIDE GD2 AS A MARKER AND TARGET ON CANCER STEM CELLS

机译：GANGLIOSIDE GD2作为癌症干细胞的标志物和靶标

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摘要

Methods for determining the presence of cancer stem cells by detecting GD2 expression. Also provided are methods for reducing proliferation of cancer stem cells by contacting the cells with a GD2 targeting agent, such as an anti-GD2 antibody or a GD3 synthase inhibitor. GD3 synthase inhibitor compounds are also provided.

机译：通过检测GD2表达来确定癌症干细胞的存在的方法。还提供了通过使细胞与GD2靶向剂如抗GD2抗体或GD3合酶抑制剂接触来减少癌症干细胞增殖的方法。还提供了GD3合酶抑制剂化合物。

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公开/公告号US2015044233A1

专利类型
公开/公告日2015-02-12

原文格式PDF
申请/专利权人 BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM;
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申请/专利号US201314380807
发明设计人 VENKATA BATTULA;MICHAEL ANDREEFF;SENDURAI A. MANI;TAPASREE ROY SARKAR;
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申请日2013-02-27
分类号G01N33/574;A61K45/06;A61K39/395;C07K16/30;
国家 US
入库时间 2022-08-21 15:25:04

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